The neural connectome of suicidality in adults with mood and anxiety disorders

Abstract

Although suicide risk is a major public health issue, attempts to understand the neural basis of suicidality have been limited by small sample sizes and a focus on specific psychiatric disorders. This sample comprised 579 participants, of whom 428 had a psychiatric disorder (depression, anxiety or stress-related disorder) and 151 were non-psychiatric controls. All participants underwent structured clinical interviews, including an assessment of suicidality in the past month, and completed a functional magnetic resonance imaging scan. There were 238 (41.1%) participants who met criteria for suicidality and 341 (58.9%) were non-suicidal. Task-derived functional connectivity was calculated for ..